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Design and development of an artificial implantable lung using multiobjective genetic algorithm: evaluation of gas
Ichiro Taga1, Akio Funakubo, Yasuhiro Fukui
1Frontier Research and Development Center, Tokyo Denki University, Ishizaka Hatoyama, Hikigun, Saitama 350-0394, Japan.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|March 5, 2005
Summary
Researchers developed an automatic system using multiobjective genetic algorithms (MOGA) to design artificial lungs. This novel approach significantly improved oxygen and carbon dioxide transfer, enhancing artificial organ development.
Area of Science:
- Biomedical Engineering
- Medical Device Design
- Computational Fluid Dynamics
Background:
- Artificial organs require high antithrombogenicity and gas exchange efficiency.
- Optimizing artificial lung design traditionally involves time-consuming and labor-intensive processes.
Purpose of the Study:
- To construct an automatic optimization system for designing artificial implantable lungs.
- To enhance antithrombogenicity and gas exchange performance using fluid dynamics principles.
Main Methods:
- Integration of a 3D CAD system, computational fluid dynamics (CFD) software, and the modeFRONTIER optimization tool.
- Application of multiobjective genetic algorithms (MOGA) to optimize design variables, minimizing thrombus formation (ObjTF) and maximizing gas exchange performance (ObjGEP).
- Two-stage optimization process involving inflow/outflow portions and edge refinements, followed by rapid prototyping and in vitro testing.
Main Results:
- The optimization system successfully improved artificial lung designs.
- The optimal design demonstrated a 74.8% improvement in ObjGEP.
- Significant increases in gas exchange: 18.4% for O2 transfer and 40.5% for CO2 transfer compared to the original design.
Conclusions:
- The developed automatic optimization system is effective for artificial organ development.
- This system reduces development time, cost, and labor.
- It serves as a valuable tool for designing high-performance artificial organs for transplantation.