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Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve
James S Tweddell1, Andrew N Pelech, Peter C Frommelt
1Herma Heart Center, Children's Hospital of Wisconsin, Milwaukee 53226, USA. jtweddell@chw.org
Insights
Aortic valve repair in children shows promising results, with simple repairs offering excellent long-term outcomes. Complex repairs demonstrated similar reintervention rates to valve replacement, suggesting its utility in pediatric cases.
Area of Science:
- Pediatric Cardiac Surgery
- Congenital Heart Disease
- Aortic Valve Interventions
Background:
- Aortic valve disease in children presents unique challenges.
- Surgical repair aims to preserve native valve function.
- Understanding the long-term efficacy of different repair techniques is crucial.
Purpose of the Study:
- To evaluate the utility and long-term outcomes of aortic valve repair in pediatric patients.
- To compare the effectiveness of various aortic valve repair strategies against valve replacement.
Main Methods:
- Retrospective analysis of aortic valve surgeries performed between 1973 and 2004.
- Classification of procedures into simple repairs, repair of aortic insufficiency with VSD, complex repairs, and replacements.
- Assessment of freedom from reintervention and residual valve dysfunction.
Main Results:
- Simple repairs and repair of aortic insufficiency with VSD showed high freedom from reintervention (>86% at 10 years).
- Complex repairs had comparable freedom from reintervention to valve replacement (44% vs. 77% at 10 years, P = .3).
- Patients undergoing complex repair had acceptable residual gradients and were free of severe aortic insufficiency.
Conclusions:
- Aortic valve repair is a viable option for children, offering excellent outcomes for simple repairs.
- Complex aortic valve repair demonstrates comparable long-term reintervention rates to valve replacement.
- Residual aortic stenosis, not the initial diagnosis, predicted the need for reintervention.
Objective:
This study was undertaken to determine the utility of aortic valve repair in children.
Methods:
A retrospective analysis was conducted on aortic valve surgery from 1973 to 2004 at Children's Hospital of Wisconsin.
Results:
Procedures were classified as simple repairs (blunt valvotomy, commissurotomy with or without thinning, n = 147), repair of aortic insufficiency with ventricular septal defect (n = 22), complex repairs (any combination of additional procedures including suspension of prolapsed leaflets, leaflet extensions, repair of torn or perforated leaflets, annuloplasty, reduction of sinus of Valsalva plasty, and concomitant repair of supravalvular or subvalvular stenosis, n = 57), and replacements (n = 57, 20 mechanical, 2 porcine, and 35 human valves). Freedoms from reintervention for simple repairs and repair of aortic insufficiency with ventricular septal defect at 10 years were 86% +/- 5% and 93.3% +/- 6%, respectively. For complex valve repair, freedoms from reintervention at 1, 5, and 10 years were 94% +/- 3%, 85% +/- 6%, and 44% +/- 15%, versus 96% +/- 3%, 77% +/- 9%, and 77% +/- 9% for valve replacement ( P = .3). At intermediate follow-up, patients with complex valve repair had a residual gradient of 20 +/- 21 mm Hg, and 94% were free of severe aortic insufficiency. Residual aortic stenosis ( P < .05) but not the preoperative diagnosis of combined aortic stenosis and insufficiency predicted the need for reintervention.
Conclusion:
Freedom from reintervention after complex valve repairs was not different from that after valve replacement, with acceptable residual aortic stenosis and insufficiency. Simple repairs and repair of aortic insufficiency with ventricular septal defect yielded excellent long-term freedom from reintervention.
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