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A novel HLA-haplotype containing a DRB5 gene not associated with DRB1*15 or DRB1*16 alleles
1Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin Ruhr-Universität, Bochum, Germany.
Tissue Antigens
|February 1, 1992
Abstract:
In Caucasians, HLA-DR2 haplotypes usually express two DRB genes encoding the DR specificity. The DRB5 genes are in strong linkage disequilibrium with the respective DRB1*15 or DRB1*16 alleles. So far, no other DRB1 alleles have been found in association with DRB5 genes. Here, we report evidence for a probably recombinant DRB5 haplotype with a DRB1 allele not specific for DR2. From our results the haplotype DQB1*0501, DRB1*0101 and DRB5*0101 seems most likely.