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ISCOM-based vaccines: the second decade

Megan T Sanders1, Lorena E Brown, Georgia Deliyannis

  • 1Department of Microbiology and Immunology, The University of Melbourne, Australia.

Immunology and Cell Biology
|March 8, 2005
PubMed

The immunostimulating complex or 'iscom' was first described 20 years ago as an antigen delivery system with powerful immunostimulating activity. Iscoms are cage-like structures, typically 40 nm in diameter, that are comprised of antigen, cholesterol, phospholipid and saponin. ISCOM-based vaccines have been shown to promote both antibody and cellular immune responses in a variety of experimental animal models. This review focuses on the evaluation of ISCOM-based vaccines in animals over the past 10 years, as well as examining the progress that has been achieved in the development of human vaccines based on ISCOM adjuvant technology.

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