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[The study on pathogenesis of latex allergy.]
1The Department of Immunology and Rheumatology, Qingdao Municipal Hospital, Qingdao 266011, China.
Summary
Latex allergy is prevalent, with high rates of specific IgE found in patients. High-risk individuals should be screened for latex allergy to implement protective measures.
Area of Science:
- Immunology
- Occupational Health
Context:
- Latex allergy poses a significant risk in occupational settings.
- Understanding its pathogenesis is crucial for disease prevention and management.
Purpose:
- To investigate the pathogenesis of latex allergy.
- To determine the significance of latex allergy in occupational disease prevention and treatment.
Summary:
- A study involving 651 outpatients utilized skin prick tests (SPT) and detected specific IgE (sIgE) to latex via disk ELISA and Western-blot.
- Higher positive rates for latex SPT (37.5%) and sIgE (31.25%) were observed in patients compared to controls.
- The high-risk group exhibited significantly higher latex sIgE positivity than low-risk and normal groups, with patient sera reacting to multiple bands in latex glove extracts.
Impact:
- The high prevalence of IgE-mediated latex allergy necessitates targeted screening.
- Recommendations include screening high-risk populations for latex allergy to enable appropriate occupational and daily protective strategies.