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Updated: Aug 19, 2026

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Spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated

Joseph R Tumang1, Rubén Francés, Seung Geun Yeo

  • 1Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|March 8, 2005
PubMed

B-1 cells spontaneously secrete natural Ig that acts as a primary line of defense against infection. A major shortfall in our understanding of this key process centers on the molecular mechanisms regulating natural Ab secretion by B-1 cells. Herein, we demonstrate that secreting B-1 cells use some aspects of the recently recognized plasmacytic differentiation program but deviate from it in important ways. Specifically, we show that key repressors of the plasmacytic program, B cell leukemia/lymphoma-6 and paired box gene 5, are reduced in spontaneously secreting B-1 B cells, as in stimulated differentiated B-2 cells. Surprisingly, we find that key promoters of the plasmacytic program, B lymphocyte inducer of maturation program 1 and X-box binding protein 1, are not up-regulated in secreting B-1 cells, in contrast to secreting B-2 cells. These data demonstrate that B-1 cells operate under a differentiation program that is unique and differs from the paradigm associated with Ig-secreting B-2 cells.

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