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Final height in patients with constitutional delay of growth and development from tall statured families

Otfrid Butenandt1, Susanne Bechtold, Annette Meidert

  • 1Dr. von Haunersches Kinderspital, University of Munich Auxologic Working Group, Munich, Germany. otfrid@butenandt.de

Journal of Pediatric Endocrinology & Metabolism : JPEM
|March 9, 2005
PubMed

Insights

Constitutional delay of growth and development (CDGD) affects boys and girls equally, regardless of family height. Most children achieve normal final heights within their familial target range without intervention.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Background:

  • Constitutional delay of growth and development (CDGD) is a common cause of short stature in children.
  • It can occur in families of both short and tall stature.

Purpose of the Study:

  • To evaluate the final height outcomes in children with CDGD.
  • To determine if CDGD affects boys and girls differently.
  • To assess the necessity of therapeutic interventions for CDGD.

Main Methods:

  • Retrospective analysis of 33 patients (12 boys, 21 girls) diagnosed with CDGD.
  • Comparison of final achieved height with mean target height and familial target height range.

Main Results:

  • The mean target height for boys was 186.6 cm and for girls 173.6 cm; final heights were 191.2 cm and 176.9 cm, respectively.
  • 14 patients exceeded their mean target height by over 4 cm.
  • Nine patients exceeded their familial target height range; only one boy did not reach it.

Conclusions:

  • CDGD occurs equally in boys and girls, irrespective of familial height.
  • Children with CDGD typically achieve normal final heights within their familial target range.
  • Intervention is generally not required for CDGD.

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