D-type fiber biosensor based on surface-plasmon resonance technology and heterodyne interferometry

Area of Science:

• Optoelectronics
• Biomedical Engineering
• Chemical Sensing

Background:

• Surface-plasmon resonance (SPR) is a powerful technique for detecting changes in refractive index.
• Traditional SPR methods often rely on intensity measurements, which can be limited in accuracy and resolution.
• Optical fiber-based sensors offer advantages in miniaturization and remote sensing capabilities.

Purpose of the Study:

• To develop a novel D-type fiber biosensor.
• To leverage surface-plasmon resonance (SPR) technology combined with heterodyne interferometry.
• To enhance the accuracy, resolution, and sensitivity of biosensing.

Main Methods:

• Fabrication of a D-type optical fiber with a polished core and gold thin-film deposition.
• Utilizing heterodyne interferometry to measure phase-difference variations.
• Employing the sensor for chemical, biological, and biochemical detection.

Main Results:

• Achieved high accuracy and resolution by measuring phase differences instead of light intensity.
• Demonstrated a sensitivity of 2 x 10^-6 refractive index units.
• The D-type fiber biosensor exhibited tunable high sensitivity, small size, and suitability for in vivo testing.

Conclusions:

• The presented D-type fiber biosensor based on SPR and heterodyne interferometry offers superior performance.
• This novel biosensing approach is valuable for diverse applications in chemical, biological, and biochemical analysis.
• The D-type fiber biosensing method provides a feasible and effective means for advanced studies.