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Related Experiment Videos

Antiangiogenic potency of vitamin E.

Teruo Miyazawa1, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa

  • 1Food and Biodynamic Chemistry Lab, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan. miyazawa@biochem.tohoku.ac.jp

Annals of the New York Academy of Sciences
|March 9, 2005
PubMed
Summary

Tocotrienols (T3), a form of vitamin E, show significant anti-angiogenic properties, inhibiting new blood vessel formation. Delta-T3 demonstrated the highest efficacy, suggesting potential as a dietary supplement for angiogenic disorders.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Cell Biology

Background:

  • Angiogenesis is crucial for tumor growth and metastasis.
  • Vitamin E compounds, including tocotrienols (T3) and tocopherol (Toc), are studied for their health benefits.
  • Tocotrienols are natural analogues of tocopherols with distinct biological activities.

Purpose of the Study:

  • To investigate the antiangiogenic properties and mechanisms of vitamin E compounds, focusing on tocotrienols.
  • To compare the efficacy of tocotrienols (T3) and tocopherol (Toc) in inhibiting angiogenesis.
  • To explore the molecular pathways involved in the antiangiogenic effects of T3.

Main Methods:

  • In vitro assays using bovine aortic endothelial cells and human umbilical vein endothelial cells to assess proliferation and tube formation.

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  • In vivo assays including the chick embryo chorioallantoic membrane assay and the mouse dorsal air sac assay to evaluate angiogenesis.
  • DNA microarray analysis to identify molecular targets and signaling pathways affected by T3.

    • Main Results:

    • Tocotrienols (T3), particularly delta-T3, significantly inhibited endothelial cell proliferation and tube formation.
    • Delta-T3 reduced vascular endothelial growth factor (VEGF)-stimulated angiogenesis in vitro and in vivo.
    • Orally administered T3 suppressed tumor cell-induced angiogenesis in a mouse model.
    • Tocopherol (Toc) exhibited minimal antiangiogenic activity compared to T3.
    • DNA microarray analysis indicated that T3's antiangiogenic effects involve the regulation of intracellular VEGF signaling pathways (e.g., phospholipase C-gamma, protein kinase C).

    Conclusions:

    • Tocotrienols, especially delta-T3, possess potent antiangiogenic properties.
    • T3 effectively inhibits angiogenesis through mechanisms involving VEGF signaling.
    • Tocotrienols show promise as therapeutic dietary supplements for preventing or managing angiogenic disorders.