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Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Tocopherol in lipoproteins and blood cells after cardiac surgery

M Hacquebard1, A Ducart, D Schmartz

  • 1Laboratory for Experimental Surgery L. Deloyers. Université Libre de Bruxelles, Avenue J. Wybran 40, 1070 Brussels, Belgium. Mirjam.Hacquebard@ulb.ac.be

Annals of the New York Academy of Sciences
|March 9, 2005
PubMed

Insights

Cardiac surgery significantly reduced LDL and HDL particles, impacting alpha-tocopherol transport. This led to lower alpha-tocopherol in white blood cells, with increased LDL and HDL hydroperoxides post-surgery.

Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Lipid Metabolism

Background:

  • Cardiac surgery is a major physiological stressor.
  • Lipoprotein metabolism plays a crucial role in nutrient transport, including antioxidants like alpha-tocopherol.
  • Understanding post-surgical changes in lipid profiles is vital for patient recovery.

Purpose of the Study:

  • To investigate the impact of cardiac surgery on circulating lipoproteins.
  • To assess alterations in alpha-tocopherol (vitamin E) transport and levels post-cardiac surgery.
  • To evaluate changes in lipoprotein oxidative status after cardiac surgery.

Main Methods:

  • Analysis of LDL and HDL particle concentrations before and after cardiac surgery.
  • Measurement of alpha-tocopherol levels in various blood components (WBCs, PLTs, RBCs).
  • Assessment of hydroperoxide content in LDL and HDL particles.

Main Results:

  • A significant reduction in circulating low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles was observed.
  • Alpha-tocopherol levels decreased in white blood cells (WBCs) but remained unchanged in platelets (PLTs) and red blood cells (RBCs).
  • Increased hydroperoxide content was detected in LDL and potentially in HDL post-surgery.

Conclusions:

  • Cardiac surgery profoundly affects lipoprotein metabolism and antioxidant transport.
  • Reduced lipoprotein levels and increased oxidative stress may impair alpha-tocopherol delivery to cells.
  • Further research is needed to understand the clinical implications of these biochemical changes.

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