Related Experiment Videos
[Quantitative morphometry of hyperplastic hypoechoic nodules in the prostatic outer gland]
Xin Li1, Na Wang, Huai-Yin Shi
1Department of Ultrasonics, General Hospital of PLA, Beijing 100853, China. lx0803@sina.com.en
Zhonghua Nan Ke Xue = National Journal of Andrology
|March 10, 2005
Summary
Benign hypoechoic nodules in the prostate outer gland show distinct morphotic characteristics. These findings differentiate them from nodules in the inner gland, suggesting varied development pathways.
Area of Science:
- Urology
- Pathology
- Medical Imaging
Background:
- Hypoechoic nodules in the prostate are often associated with benign prostatic hyperplasia.
- The outer gland of the prostate is a less common site for these nodules compared to the inner gland.
Purpose of the Study:
- To investigate the morphotic characteristics of hypoechoic nodules located in the outer gland of the prostate.
- To compare the cellular composition of outer gland nodules with those found in the inner gland.
Main Methods:
- Twenty-two hyperplastic hypoechoic nodules from the prostatic outer gland were targeted for biopsy.
- Transrectal ultrasound guided the biopsies.
- Hematoxylin-eosin staining and immunohistochemistry were employed, followed by computer-assisted quantitative image analysis.
Main Results:
- The mean area densities for stroma, epithelium, glandular lumen, and smooth muscle cells were determined.
- Stroma constituted the largest component (72.52% ± 13.14%), followed by smooth muscle cells (24.14% ± 6.31%), epithelium (20.57% ± 9.01%), and glandular lumen (6.85% ± 4.51%).
Conclusions:
- Benign hypoechoic nodules can occur in the prostate's outer gland.
- The composition of these outer gland nodules differs significantly from those found in the inner gland, indicating distinct pathological features.