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Optic neuropathy associated with linezolid treatment
Steven H McKinley1, Rod Foroozan
1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Summary
Long-term linezolid treatment can cause toxic optic neuropathy, affecting vision. Stopping the antibiotic may lead to slow visual recovery in patients.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Linezolid is a critical antibiotic for treating serious infections, including pneumonia.
- Long-term antibiotic use necessitates careful monitoring for potential adverse effects.
- Toxic optic neuropathy is a rare but serious condition affecting vision.
Observation:
- Two patients on long-term linezolid therapy for pneumonia developed visual disturbances.
- Symptoms included decreased visual acuity, color vision deficits (dyschromatopsia), and central vision blind spots (cecocentral scotomas).
- These clinical signs are indicative of toxic optic neuropathy.
Findings:
- The observed visual impairments were characteristic of linezolid-induced toxic optic neuropathy.
- Following discontinuation of linezolid, both patients experienced gradual improvement in visual function.
- Visual recovery occurred over a period of 3 to 4 months post-treatment.
Implications:
- Linezolid may be associated with the development of toxic optic neuropathy.
- Early detection and cessation of linezolid treatment are crucial for potential visual recovery.
- Ophthalmologists and infectious disease specialists should be aware of this potential adverse effect.