Related Experiment Video
Updated: Aug 14, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Carcinoma of unknown primary site
Ali R Hashim1, Ahmed M Al-Quryni
1Department of Medicine, Basrah Teaching Hospital, Basrah Medical College, Basrah, Iraq. alinz12@yahoo.com
Carcinoma of unknown primary site (CUP) presents with varied symptoms and histopathology. Poor prognostic factors include older age, smoking, adenocarcinoma, and multiple metastases, impacting patient survival.
Area of Science:
- Oncology
- Clinical Research
Background:
- Carcinoma of unknown primary site (CUP) presents a diagnostic challenge.
- Understanding its manifestations and prognostic factors is crucial for patient management.
Purpose of the Study:
- To characterize the spectrum of CUP manifestations, histopathological types, and patient outcomes.
- To identify prognostic factors influencing patient survival in CUP.
Main Methods:
- A cohort of 60 patients diagnosed with CUP between January 2001 and July 2002 was retrospectively studied.
- Data collected included patient demographics, metastatic sites, histopathology, and survival outcomes.
Main Results:
- Adenocarcinoma was the most common type (63%).
- Liver and bone were frequent sites of metastasis.
- Smoking and weight loss were common patient presentations.
- Age > or = 60, smoking, adenocarcinoma, and multiple metastases were associated with poorer outcomes.
Conclusions:
- Significant demographic differences were observed between male and female patients regarding age.
- Prognostic factors identified include age, smoking status, histopathological type, and extent of metastasis.
- Mean survival was limited to 2.4 months, highlighting the aggressive nature of CUP.
More Related Videos
08:17Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
Published on: December 9, 2016
09:28Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
Related Concept Videos
Cancer
Cancers Originate from Somatic Mutations in a Single Cell
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancers Originate from Somatic Mutations in a Single Cell
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...