Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Identification of functional modules in protein complexes via hyperclique pattern discovery.

Hui Xiong1, Xiaofeng He, Chris Ding

  • 1Computer Science & Engineering, University of Minnesota, MN, USA. huix@cs.umn.edu

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
|March 12, 2005
PubMed
Summary

This study introduces a hyperclique pattern discovery method to identify functional modules within protein complexes. This approach accurately extracts protein groups with shared functions and interactions, enhancing biological pathway understanding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weighted Sparse Partial Least Squares With Joint Sample and Feature Selection for Integrating Multi-Omics Data.

IEEE transactions on computational biology and bioinformatics·2025
Same author

Contrastive independent subspace analysis network for multi-view spatial information extraction.

Neural networks : the official journal of the International Neural Network Society·2025
Same author

Tensorized Bipartite Graph Learning for Multi-View Clustering.

IEEE transactions on pattern analysis and machine intelligence·2022
Same author

A Modified Two-Layer Suture Technique for Transperitoneal Laparoscopic Partial Nephrectomy: Single-Center Clinical Experience.

Frontiers in surgery·2022
Same author

New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells.

Journal of immunology research·2022
Same author

Contribution of recycled moisture to precipitation and its influencing factors in the subalpine zone of Qilian Mountains.

Environmental science and pollution research international·2022

Area of Science:

  • Computational Biology
  • Systems Biology
  • Bioinformatics

Background:

  • Proteins function in complex cellular pathways, interacting in pairs or larger complexes.
  • Identifying functional modules within protein complexes is challenging due to false-positive interactions in current datasets.
  • Accurate understanding of functional modules is crucial for deciphering elementary biological functions.

Purpose of the Study:

  • To present a novel hyperclique pattern discovery approach for extracting functional modules from protein complexes.
  • To validate the biological significance and functional coherence of identified hyperclique patterns.
  • To demonstrate the utility of hyperclique patterns in understanding protein complex organization and function.

Main Methods:

  • Developed a hyperclique pattern discovery approach to analyze protein complexes.

Related Experiment Videos

  • Utilized Gene Ontology annotations for statistical analysis of protein functions within patterns.
  • Applied 3-D structural analysis to investigate physical interactions among proteins in hyperclique patterns.

    • Main Results:

    • Hyperclique patterns effectively extract groups of highly affiliated proteins from protein complexes.
    • Proteins within the same hyperclique pattern exhibit statistically significant functional and biological process annotations.
    • 3-D structural analysis confirms physical interactions among proteins within identified hyperclique patterns.
    • Demonstrated that single protein complexes can contain multiple independent hyperclique patterns with distinct functions.
    • Showcased that a single hyperclique pattern can participate in various complexes, contributing to different higher-order functions.

    Conclusions:

    • The hyperclique pattern discovery approach accurately identifies functional modules within protein complexes.
    • Hyperclique patterns provide insights into protein-protein interactions, shared functions, and biological processes.
    • This method enhances the understanding of modular organization and functional versatility of protein complexes in cellular pathways.