[Advances in gene expression of bone marrow stromal cells]

To review the advances in gene expression of marrow stromal cells (MSCs) in biological characteristic, differentiation, gene therapy, supporting hematopoiesis, inflammation reaction in wound repair.

The related articles in recent years were extensively reviewed.

MSCs can express not only specific mRNA of mesodermal cells but also that of endodermal and ectodermal cell types on various differentiation conditions. When transfected or transduction, MSCs can steadily express many therapeutic transgenes in vitro or in vivo as well. Furthermore, they have the ability to support hematopoietic system and participate in the process of inflammation in wound repair.

MSCs are stem cells which have the characteristic of self renewing, multi-potency and easy to expand in vitro. MSCs are ideal target cells for cell and gene therapies.