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Related Experiment Videos

In vitro evaluation of a morphine polymeric complex: flowability behavior and dissolution study.

Mercedes Fernández-Arévalo1, Josefa Alvarez-Fuentes, Ana Iruin

  • 1Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Sevilla.

AAPS Pharmscitech
|March 12, 2005
PubMed
Summary

This study characterized morphine polymeric complex flow properties and dissolution. Ionic strength significantly impacts dissolution at sub-physiological levels, but not within the normal physiological range.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Polymeric complexes offer advanced drug delivery systems.
  • Morphine's therapeutic potential can be enhanced through complexation.

Purpose of the Study:

  • To evaluate the granulometrical and flow properties of a morphine-Eudragit L polymeric complex.
  • To determine the influence of particle size, pH, and ionic strength on the complex's dissolution behavior.

Main Methods:

  • Morphine-Eudragit L complex synthesis in an aqueous medium.
  • Rheological tests including bulk/tapped densities, Hausner ratio, angle of repose, and flow rate.
  • Dissolution studies assessing particle size, pH, and ionic strength effects.

Main Results:

  • The 100- to 250-micrometer fraction exhibited free-flowing powder characteristics.

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  • Ionic strength was the primary factor influencing dissolution at sub-physiological conditions.
  • Dissolution profiles remained stable within the physiological ionic strength range.

    • Conclusions:

    • The morphine-Eudragit L complex demonstrates favorable technological properties for solid dosage form production.
    • No significant alterations in dissolution are anticipated for in vivo applications within physiological ionic strength.
    • Further development of solid dosage forms utilizing this complex is feasible.