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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Enhanced Metabolic Syndrome Management Through Cannabidiol-Loaded PLGA Nanoparticles: Development and In Vitro

Mazen M El-Hammadi¹, Lucía Martín-Navarro¹, Esther Berrocoso^2,3,4

¹Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, Sevilla, Spain.

Journal of Biomedical Materials Research. Part A

|April 25, 2025

Summary

Polymeric nanoparticles effectively delivered cannabidiol (CBD) for metabolic disorders. This novel nanoformulation improved glucose uptake and lipid profiles in vitro, showing promise for managing metabolic diseases.

Keywords:

antipsychotics cannabidiol diabetes lipid metabolism metabolic disorders nanomedicine

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Published on: September 18, 2018

Area of Science:

Biomedical Engineering
Pharmacology
Metabolic Disease Research

Background:

Metabolic diseases pose a significant health challenge.
Cannabidiol (CBD) shows potential for metabolic disease management.
Improving CBD's oral bioavailability and efficacy is crucial.

Purpose of the Study:

To develop and evaluate poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) encapsulating CBD.
To assess the therapeutic efficacy of CBD-loaded NPs in an in vitro metabolic syndrome model.

Main Methods:

CBD was encapsulated into PLGA NPs via nanoprecipitation.
NPs were characterized for size, encapsulation efficiency, and release kinetics.
In vitro assays used sodium palmitate-induced HepG2 cells to assess cell viability, glucose uptake, lipid accumulation, and gene expression.

Main Results:

CBD-loaded NPs exhibited high encapsulation efficiency (~100%) and sustained release.
CBD-NPs significantly improved glucose uptake and reduced lipid accumulation, triglycerides, and cholesterol.
Gene expression analysis revealed modulated pathways for gluconeogenesis and fatty acid oxidation.

Conclusions:

CBD-loaded PLGA NPs represent a promising strategy for metabolic disorder treatment.
The nanoformulation enhanced CBD's therapeutic effects in vitro.
Further in vivo studies are warranted to confirm efficacy.