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Related Experiment Videos

Premenopausal bone health assessment.

E Michael Lewiecki1

  • 1New Mexico Clinical Research & Osteoporosis Center, 300 Oak St. NE, Albuquerque, NM 87106, USA. lewiecki@aol.com

Current Rheumatology Reports
|March 12, 2005
PubMed
Summary
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The World Health Organization

Area of Science:

  • Endocrinology and Bone Health

Background:

  • World Health Organization (WHO) bone mineral density (BMD) criteria are not applicable to premenopausal women.
  • The relationship between BMD and fracture risk differs between premenopausal and postmenopausal women.

Purpose of the Study:

  • To evaluate the clinical significance of low bone mineral density (BMD) in premenopausal women.
  • To differentiate between premenopausal women with low BMD and low fracture risk versus those with elevated risk.

Main Methods:

  • Analysis of BMD in premenopausal women compared to age-, gender-, and ethnicity-matched reference populations.
  • Assessment of fracture risk factors in premenopausal women with low BMD.

Main Results:

  • Approximately 2.5% of premenopausal women exhibit BMD more than 2.0 standard deviations below the mean.

Related Experiment Videos

  • Most premenopausal women with low BMD have low peak bone mass and low short-term fracture probability.
  • A minority of premenopausal women with low BMD have significantly elevated fracture risk due to underlying conditions or medications.

    • Conclusions:

    • Low BMD in premenopausal women often indicates low peak bone mass with minimal fracture risk.
    • Identifying underlying causes is crucial for the minority of premenopausal women with elevated fracture risk.
    • Premenopausal women experiencing fractures face increased risk of future osteoporosis and fractures.