Related Experiment Video
Updated: Feb 16, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Severity of silicosis at compensation between medically screened and unscreened workers
1Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, 1130 Pine Avenue West, Montréal, Québec, Canada H3A 1A3. claire.infante-rivard@mcgill.ca
Objective:
Most developed countries have medical surveillance programs for some of the workers (typically miners) exposed to silica, but the impact of these programs is not documented.
Methods:
Clinical data from 1388 compensated silicotic workers in Quebec, Canada, were used. The severity of disease at compensation was compared between workers in the surveillance program and those who were not.
Results:
Predicted vital capacity at less than 80% at compensation was less likely among workers under surveillance than among those who were not (odds ratio = 0.59; 95% confidence interval 0.44-0.80); the occurrence of a radiological image with large opacities and profusion of category 1/1 or more was also less likely in the group with surveillance (odds ratio = 0.60; 95% CI = 0.39-0.92).
Conclusions:
The data indicate a benefit from medical surveillance but alternative explanations are discussed.
Related Concept Videos
Myocarditis III: Medical Management
Endocarditis III: Medical Management
Pericarditis III: Medical Management
Dosage Compensation
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
Compensation Mechanisms
Respiratory Compensation
This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH...
Inhaled Medications

