Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute hepatitis induced by cyclofenil: a case report.

G Rossi1, E Gabbi, L Serra

  • 1Divisione di Malattie Infettive, Ospedale S. Maria Nuova, USL N 9, Reggio Emilia, Italy.

The Italian Journal of Gastroenterology
|February 1, 1992
PubMed
Summary

Cyclofenil, a drug for anovulation and scleroderma, can cause acute hepatitis. This drug-induced liver injury resolved after discontinuing cyclofenil, as confirmed by liver biopsy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyarteritis nodosa and HIV infection: no evidence of a direct pathogenic role of HIV.

Infection·1996
Same author

Dosimetry of 169 Yb seed model X1267.

Physics in medicine and biology·1995
Same author

Intensive therapy for adult acute lymphoblastic leukemia: preliminary results of the idarubicin/vincristine/L-asparaginase/prednisolone regimen.

Seminars in oncology·1993
Same author

Hepatitis C virus infection in liver allograft recipients.

Archives of virology. Supplementum·1993
Same author

Influence of basal androgen levels in euandrogenic women on glucose homeostasis.

Fertility and sterility·1992
Same author

Phenobarbital in the prophylaxis of late posttraumatic seizures.

Italian journal of neurological sciences·1992

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Toxicology

Background:

  • Cyclofenil is a medication investigated for treating anovulation and scleroderma.
  • Drug-induced liver injury (DILI) is a significant concern in clinical practice.
  • Identifying the causative agent is crucial for managing DILI.

Observation:

  • A 47-year-old woman developed acute hepatitis.
  • Hepatitis onset occurred seven weeks after initiating cyclofenil treatment.
  • Liver histology and exclusion of other causes confirmed the diagnosis.

Findings:

  • Cyclofenil administration was directly linked to the acute hepatitis.
  • Cessation of cyclofenil led to the complete reversal of liver injury.
  • Histopathological examination of the liver supported the diagnosis of drug-induced hepatitis.

Implications:

  • This case highlights cyclofenil as a potential cause of drug-induced liver injury.
  • Physicians should consider cyclofenil in the differential diagnosis of acute hepatitis.
  • Further research into the hepatotoxicity of cyclofenil is warranted.

Related Experiment Videos