Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using stem cells in multiple sclerosis therapies.

P A Muraro1, R Cassiani-Ingoni, R Martin

  • 1Neuroimmunology Branch NINDS, NIH, Bethesda, Maryland 20892-1400, USA.

Cytotherapy
|March 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relationship of age with the clinical phenotype in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2016
Same author

SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking.

Bone marrow transplantation·2014
Same author

Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis.

NeuroImage. Clinical·2014
Same author

A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis.

European journal of neurology·2013
Same author

A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper.

Multiple sclerosis (Houndmills, Basingstoke, England)·2012
Same author

Age and disability accumulation in multiple sclerosis.

Neurology·2011
Same journal

CAR T cells: The next frontier.

Cytotherapy·2026
Same journal

Dialysis bioreactor enables high-density, serum-free expansion of dental pulp-derived mesenchymal stromal cells with enhanced secretome.

Cytotherapy·2026
Same journal

Beyond the synapses: should we anticipate neurotransmitter signaling when manufacturing CAR-T cells for brain tumors?

Cytotherapy·2026
Same journal

Curative treatment for severe sickle cell disease: allogeneic hematopoietic cell transplant or gene therapy.

Cytotherapy·2026
Same journal

Manufacturing strategies for prolonged CAR-T cell persistence.

Cytotherapy·2026
Same journal

Overcoming five main challenges to targeting hematologic malignancies.

Cytotherapy·2026
See all related articles

Hematopoietic stem cell transplantation offers a potential cure for multiple sclerosis (MS). Research explores its effectiveness and myelin repair in experimental models, advancing MS therapeutics.

Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.
  • Current MS treatments primarily manage symptoms and slow progression, lacking curative potential.

Purpose of the Study:

  • To review clinical observations from hematopoietic stem cell transplantation (HSCT) trials for MS.
  • To discuss experimental findings on myelin and neural repair in demyelinating disorders.

Main Methods:

  • Analysis of clinical trial data for HSCT in MS patients.
  • Review of preclinical studies investigating myelin regeneration mechanisms.

Main Results:

  • HSCT shows promise as a potentially curative therapy for MS.

Related Experiment Videos

  • Experimental models provide insights into strategies for promoting myelin repair.

    • Conclusions:

    • Hematopoietic stem cell transplantation represents a significant advancement in MS therapeutic strategies.
    • Further research is needed to optimize HSCT and enhance neural repair in MS.