Related Experiment Video
Updated: Jun 7, 2026

Generation and Functional Verification of Hypoxia-Sensitive Chimeric Antigen Receptor-T Cells
Published on: June 14, 2024
Overcoming five main challenges to targeting hematologic malignancies
Megha Thakkar1, Patrick J Hanley2, Alexey Bersenev3
1Center for Cell and Gene Therapy, Baylor College of Medicine, and Texas Children's Hospital, Houston, Texas, USA.
None:
The development and application of chimeric antigen receptor (CAR) T-cell therapies have changed the treatment landscape of hematologic malignancies. While there are currently FDA approved products for their use in relapsed or refractory B-cell and plasma cell malignancies, ongoing research efforts strive to target difficult to treat antigens and diseases. In this review, we discuss five main challenges involving CAR-T cell products in hematologic malignancies. Additionally, we propose mechanisms to overcome these challenges that monitor adverse effects, improve universal access, enhance manufacturing platforms, and advance commercialization with the goal of optimal patient care.
More Related Videos
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Treatment Resistant Cancers
Treatment Resistent Cancers
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...