Related Experiment Video
Updated: Aug 19, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
Published on: March 17, 2023
Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with
1Skin Investigation and Technology, 20354 Hamburg, Germany. d.segger@t-online.de
Objective:
To investigate whether nutritional intervention with a proprietary formulation and other micronutrients may favourably alter skin roughness and elasticity.
Methods:
Sixty-two women aged 45-73 years participated in a double-blind, placebo-controlled trial testing the efficacy of a proprietary oral supplement for skin nutrition (Evelle), for improvement of skin elasticity and roughness. The active ingredients were vitamins C and E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and Pycnogenol.
Results:
Skin elasticity, measured using an optical cutometer, was found to be statistically significantly increased by 9% after 6 weeks of treatment compared with placebo (p=0.0351). Skin roughness, as evaluated by three-dimensional microtopography imaging, was found to be statistically significantly lowered by 6% compared with the control group after 12 weeks treatment (p=0.0157).
Conclusion:
Evelle can potentially improve visible signs of cutaneous ageing.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Renewal of Skin Epidermal Stem Cells
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
