Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environment and development of atopy.

John W Upham1, Patrick G Holt

  • 1Division of Cell Biology, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia. johnu@ichr.uwa.edu.au

Current Opinion in Allergy and Clinical Immunology
|March 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustained clinical remission and relapse of severe eosinophilic asthma following long-term mepolizumab treatment.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

A Real-World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Finding cures for asthma: new paradigms for drug discovery and therapy.

The Medical journal of Australia·2025
Same author

Mepolizumab treatment and reduced oral corticosteroid exposure improves symptoms of depression and anxiety in severe eosinophilic asthma: data from the Australian Mepolizumab Registry.

Respiratory medicine·2025
Same author

Atopy-related immune profiles are subject to genetic influence as evaluated using school-aged twin pairs.

Science advances·2025
Same author

Impact of clinical remission on quality of life in severe eosinophilic asthma treated with mepolizumab.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same journal

Biosimilars in allergology: an outline in pediatric patients.

Current opinion in allergy and clinical immunology·2026
Same journal

The immunogenetic landscape of systemic lupus erythematosus.

Current opinion in allergy and clinical immunology·2026
Same journal

Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders.

Current opinion in allergy and clinical immunology·2026
Same journal

Probiotics in allergic disease: from adjunct supplement to immune-modifying strategy (2026 update).

Current opinion in allergy and clinical immunology·2026
Same journal

Updates on drug-induced anaphylaxis in children.

Current opinion in allergy and clinical immunology·2026
Same journal

Beta-lactam de-labelling as a core antimicrobial stewardship strategy in the era of the antimicrobial resistance pandemic: a narrative review.

Current opinion in allergy and clinical immunology·2026
See all related articles

Environmental factors significantly influence childhood atopic disorders like asthma. Early life exposures, including allergens and infections, play a critical role in allergic sensitization and disease development.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health Sciences

Background:

  • Asthma and atopic disorders arise from complex genetic and environmental interactions.
  • Rising asthma prevalence suggests a significant role for environmental factors in allergic sensitization.

Purpose of the Study:

  • To review current research on environmental influences on childhood atopy development.
  • To highlight key environmental exposures and gene-environment interactions affecting atopic outcomes.

Main Methods:

  • Review of recent observational and interventional studies.
  • Analysis of early life environmental factors and their impact on allergic sensitization.

Main Results:

  • Early life events (pregnancy, allergen/endotoxin exposure, pets, infections, family size) critically influence atopy.

Related Experiment Videos

  • Gene-environment interactions modify the relationship between environmental exposures and atopic outcomes.

    • Conclusions:

    • Further research is needed to define environmental roles in allergic sensitization.
    • Developing targeted allergy prevention strategies for high-risk children is a future goal.