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Three-dimensional model system of valvulogenesis.

Richard L Goodwin1, Tresa Nesbitt, Robert L Price

  • 1Department of Cell and Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA. rgoodwin@med.sc.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|March 15, 2005
PubMed
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A novel 3D collagen tube system supports embryonic atrioventricular (AV) cushion development. This system recapitulates AV valve formation, highlighting the crucial role of cardiac myocytes in valve leaflet development.

Area of Science:

  • Developmental biology
  • Cardiovascular research
  • Tissue engineering

Background:

  • Valvular defects are common and severe cardiac malformations.
  • Early cardiac cushions in the embryonic atrioventricular (AV) canal are precursors to cardiac valves and septa.
  • Mechanisms of AV cushion differentiation into valve leaflets remain poorly understood.

Purpose of the Study:

  • To evaluate a novel 3D collagen tube culturing system for sustaining AV cushion anlagen development and maturation.
  • To investigate the recapitulation of AV valve development in vitro.
  • To determine factors influencing valve leaflet formation.

Main Methods:

  • Development and testing of a three-dimensional collagen tube culturing system.
  • Culturing of AV cushion anlagen within the collagen tube scaffold.

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  • Molecular and morphological analysis of developed AV cushion tissues.

    • Main Results:

    • The 3D collagen tube system successfully sustained AV cushion anlagen development and maturation.
    • Cultured AV cushion tissues recapitulated key aspects of AV valve development at molecular and morphological levels.
    • Valve leaflet formation was found to be dependent on the presence of cardiac myocytes.

    Conclusions:

    • The 3D collagen tube system is a viable model for studying AV valve development.
    • This model allows for investigation of the molecular and cellular processes underlying valve formation.
    • Cardiac myocytes are essential for the formation of AV valve leaflets.