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[Ventramine and lipid peroxidation in children with erosive gastroduodenitis]

V A Shcherbak, B S Khyshiktuev, T A Aksenova

    Klinicheskaia Laboratornaia Diagnostika
    |March 16, 2005
    PubMed

    Insights

    Children with erosive gastroduodenitis show increased lipid peroxidation and antioxidant activity. Ventramine treatment rapidly resolves symptoms and normalizes lipid peroxidation levels in pediatric patients.

    Area of Science:

    • Biochemistry
    • Pediatric Gastroenterology
    • Oxidative Stress

    Context:

    • Erosive gastroduodenitis in children is associated with biochemical changes.
    • Lipid peroxidation (LPO) and antioxidant activity are key markers in this condition.

    Purpose:

    • To investigate lipid peroxidation and antioxidant status in children with erosive gastroduodenitis.
    • To evaluate the efficacy of Ventramine in treating pediatric erosive gastroduodenitis.

    Summary:

    • The study examined 43 children with erosive gastroduodenitis and 20 healthy controls, aged 11-15.
    • Elevated levels of LPO products and increased antioxidant activity were observed in affected children.
    • Ventramine treatment effectively reduced clinical symptoms and normalized LPO levels.

    Impact:

    • Ventramine demonstrates therapeutic potential for pediatric erosive gastroduodenitis.
    • Understanding LPO dynamics offers insights into disease mechanisms.
    • Highlights the role of oxidative stress in pediatric gastrointestinal disorders.

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