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Updated: Aug 19, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
[Hemostasis and lipid peroxidation in the therapy of brain concussion at exacerbation]
Abstract:
130 patients with brain concussion (BC) and 30 virtually healthy subjects, aged 16 to 50, were examined for the purpose of studying the influence exerted by different drugs affecting blood coagulation, fibrinolysis, lipid peroxidation (LPO) and antioxidant protection at exacerbation. Changes of hemostasis in BC were shown to be of the adaptation nature and to depend essentially on a conducted treatment. Normalized plasma components in the hemostasis system were registered in groups receiving cavinton. The drug, when used, reduced the LPO intensity and intensified the activity of dismutase superoxide on days 9-12 after trauma.
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