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Evaluating postoperative analgesics in mice using telemetry.
Jane C Goecke1, Hani Awad, Jody Caldwell Lawson
1Department of Laboratory Animal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio 45267-0571, USA.
Comparative Medicine
|March 16, 2005
Summary
This study found that mock ova implantation in mice did not cause significant pain, as indicated by stable heart rate and blood pressure. Analgesics increased activity but did not alter other physiological measures.
Area of Science:
- Veterinary Science
- Pain Management
- Animal Models
Background:
- Assessing surgical pain in animal models is crucial for ethical research.
- Understanding the efficacy of analgesia in mice is important for experimental design.
Purpose of the Study:
- To evaluate the effectiveness of preemptive or postoperative analgesia in managing surgical pain in mice.
- To determine if a mock ova implantation procedure induces significant pain in mice.
Main Methods:
- Radiotelemetry transmitters were implanted in 28 female ICR mice.
- Mice received buprenorphine or flunixin meglumine before or after surgery, or multiple doses, or no treatment.
- Physiological parameters (heart rate, blood pressure, activity) and physical parameters (weight, consumption) were monitored.
Main Results:
- No significant changes in heart rate or blood pressure were observed in any group.
- All analgesic treatments increased mouse activity compared to pre-surgery levels.
- Reduced food consumption and body weight were noted in mice receiving multiple doses of buprenorphine.
Conclusions:
- The mock ova implantation procedure does not appear to induce sufficient pain to alter heart rate or blood pressure in mice.
- Analgesia did not consistently affect telemetry parameters, but did increase activity.
- Activity reduction in the first 6 hours post-surgery in untreated mice suggests mild discomfort.