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Skp2, the FoxO1 hunter

Elinor Dehan1, Michele Pagano

  • 1Department of Pathology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA.

Cancer Cell
|March 16, 2005
PubMed

Insights

Skp2 oncoprotein promotes cell proliferation by degrading cell cycle regulators. New research shows Skp2 targets FoxO1, a tumor suppressor, suggesting a novel mechanism in cancer development.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Skp2 (S-phase kinase-associated protein 2) is an oncoprotein.
  • Skp2 promotes cell proliferation by degrading negative cell cycle regulators.

Purpose of the Study:

  • To investigate the role of Skp2 in the degradation of FoxO1.
  • To elucidate a novel mechanism by which Skp2 may contribute to tumorigenesis.

Main Methods:

  • Ubiquitylation assays
  • Protein degradation studies
  • Analysis of transcription factor function

Main Results:

  • Skp2 directs the ubiquitylation and degradation of FoxO1.
  • FoxO1 is a member of the FoxO family of transcription factors.
  • FoxO proteins exhibit tumor suppressor functions.

Conclusions:

  • Skp2-mediated degradation of FoxO1 represents a new mechanism promoting tumorigenesis.
  • Targeting Skp2 could be a potential strategy for cancer therapy.

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