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Synthesis and optical resolution of an antiallergic agent KW4099 with thromboxane A2 antagonistic activity
1Sakai Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Osaka, Japan.
Chemical & Pharmaceutical Bulletin
|January 1, 1992
Abstract:
A new antiallergic agent with thromboxane A2 antagonistic activity, KW4099, was synthesized by a simple method. Its optical resolution was accomplished with the use of (+)- or (-)-2,2'-(1,1'-binaphthyl)phosphoric acid as a resolving agent.