Related Experiment Video
Updated: Aug 13, 2026

Imaging Ca2+ Responses During Shigella Infection of Epithelial Cells
Published on: May 24, 2018
Humoral factors of local immunity in shigellosis
Abstract:
Secretory immunoglobulins and antibodies were studied in dysentery patients of various age groups and in healthy persons. It is established that the level of IgA (mostly sIgA)) in coprofiltrates of patients is considerably increased and that the local production of sIgA starts very short (in 2--3 days) after the beginning of the disease. Specific coproantibodies are chiefly sIgA-antibodies. Increase of IgG in coprofiltrates is observed at early stages of the disease and is evidently due to transudation of serum proteins through the damaged mucosal membrane. High concentration of IgM is found mostly in coprofiltrates of children and is evidently the result of its local synthesis. -- Local immune response in shigellosis develops independently of systemic antibody formation. Increase of serum IgA level and appearance of sIgA-antibodies in sera of patients show the participation of local antibody forming system in formation of systemic immunity in intestinal infections.
Related Concept Videos
Humoral Immune Responses
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Determinants of Bacterial Pathogenicity and Virulence
Bacterial Gastroenteritis

