Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mouse models for human lung cancer.

Ralph Meuwissen1, Anton Berns

  • 1Division of Molecular Genetics and Center of Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Genes & Development
|March 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acupuncture does not work and has no place in science-based medicine.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.

Molecular oncology·2025
Same author

European cancer research requires renewed urgency.

Nature cancer·2025
Same author

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe.

Molecular oncology·2025
Same author

Novel Approach Methodologies in Modeling Complex Bioaerosol Exposure in Asthma and Allergic Rhinitis Under Climate Change.

Expert reviews in molecular medicine·2025
Same author

Editorial: Understanding the mesenchymal to epithelial transition: a much needed angle for epithelial mesenchymal plasticity.

Frontiers in cell and developmental biology·2024

New conditional mouse models accelerate lung cancer research. These models enable studying tumor development and cancer stem cells, improving preclinical therapy studies for non-small-cell lung cancer and small-cell lung cancer.

Area of Science:

  • Oncology
  • Genetics
  • Animal Models

Background:

  • Recent advancements have introduced novel mouse models for studying lung cancer.
  • These models encompass both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC).

Purpose of the Study:

  • To summarize the development and utility of new conditional mouse models for lung cancer research.
  • To highlight their advantages over traditional carcinogen-induced models.
  • To emphasize their potential for preclinical intervention studies.

Main Methods:

  • Conditional mouse tumor models utilize Cre-recombinase to activate oncogenic mutations in adult mice.
  • Tumorigenesis is initiated in specific cell populations, offering a controlled approach.
  • These models facilitate the study of tumor initiation, progression, and cancer stem cell roles.

Related Experiment Videos

Main Results:

  • Conditional mouse models represent a significant improvement over carcinogen-induced models.
  • They allow detailed investigation into the cell of origin for lung tumors.
  • These models are crucial for understanding the role of cancer stem cells in tumor maintenance.

Conclusions:

  • New conditional mouse models offer enhanced capabilities for lung cancer research.
  • Validation of these models is essential for preclinical studies on therapy response and resistance.
  • These models are pivotal for advancing our understanding of lung cancer biology and treatment strategies.