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Megacystis microcolon intestinal hypoperistalsis syndrome
1Children's Research Centre, Our Lady's Hospital for Sick Children, University College Dublin, Ireland. prem.puri@ucd.ie
Seminars in Pediatric Surgery
|March 17, 2005
Summary
Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a severe congenital intestinal obstruction. This review details MMIHS pathogenesis, clinical, radiological, surgical, and histological findings in reported cases.
Area of Science:
- Pediatric Surgery
- Neonatology
- Gastroenterology
Background:
- Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare, severe congenital functional intestinal obstruction.
- Key features include abdominal distension, bile-stained vomiting, and absent bowel peristalsis.
- Urinary bladder distension often causes abdominal distension, with many patients unable to void spontaneously.
Purpose of the Study:
- To review the pathogenesis of MMIHS.
- To consolidate clinical, radiological, surgical, and histological findings from reported cases.
Main Methods:
- Comprehensive literature review of MMIHS cases.
- Analysis of reported clinical presentations.
- Synthesis of radiological, surgical, and histological data.
Main Results:
- MMIHS presents with significant abdominal distension due to bladder distension and intestinal hypoperistalsis.
- Affected neonates exhibit vomiting and lack of spontaneous voiding.
- Pathogenesis involves complex functional obstruction, with varied histological findings.
Conclusions:
- MMIHS is a critical neonatal condition requiring thorough understanding of its multifaceted presentation.
- Reviewing existing case data aids in comprehending MMIHS pathogenesis and management.
- Further research into MMIHS etiology and treatment is warranted.