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[Systemic scleroderma: 92 cases in Dakar].

D Dia, M T Dieng, T N Sy

    Dakar Medical
    |March 18, 2005
    PubMed
    Summary
    This summary is machine-generated.

    Systemic scleroderma affects younger Black populations, with skin and pigment changes being common. Raynaud

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    Area of Science:

    • Rheumatology
    • Dermatology
    • Epidemiology

    Context:

    • Systemic scleroderma is a chronic autoimmune disease with significant morbidity.
    • Characterizing epidemiological data is crucial for understanding disease prevalence and presentation in diverse populations.
    • Previous studies on systemic scleroderma in Sub-Saharan Africa are limited.

    Purpose:

    • To describe the epidemiological features and clinical manifestations of systemic scleroderma in Senegal.
    • To identify key signs and symptoms in a West African cohort.
    • To compare findings with existing literature on systemic scleroderma.

    Summary:

    • A retrospective study of 92 patients in Senegal diagnosed with systemic scleroderma according to ACR criteria.
    • The mean age was 33 years, with a female predominance (77 women, 15 men). 8.9% were children.
    • Common initial complaints included cutaneous manifestations (64%) and Raynaud's syndrome (16.3%). At admission, mucocutaneous (100%), osteoarticular/muscular (59%), and Raynaud's syndrome (57%) were prevalent. Focal hypopigmentation was noted in 70%. Anti-nuclear antibodies were positive in 67.4%. Abnormal ECG (55%), non-specific inflammatory syndrome (44%), and abnormal pulmonary function (52%) were observed.

    Impact:

    • Suggests systemic scleroderma may be more prevalent in younger individuals within the Black population.
    • Highlights the high frequency of pigmentation disorders and the relative uncommonness of Raynaud's syndrome in this cohort.
    • Provides valuable epidemiological and clinical data for systemic scleroderma in Senegal, aiding in diagnosis and management strategies.