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Published on: February 10, 2015
[Autoimmune cholangitis or seronegative biliary cirrhosis: report of one case]
1Clinique médicale I, Hôpital A. Le Dantec, Dakar. sndongo_medinterne@yahoo.fr
Introduction:
Auto-immune cholangitis appears by a table of cholestatic jaundice without anomalies of the hepatic bile ducts. It is a primitive biliary cirrhosis without antimitochondrial antibodies. This disease is reported at adult women in 90 % of cases. We report a 59 years old man case.
Observation:
The patient was admitted for a diffuse melanodermy, a physical asthenia and a slimming which preceded 4 months by a pruritus with cholestatic jaundice. Biology showed a normal rate of transaminase. Alkaline phosphatases and direct bilirubine were high. Hepatitis (B and C) and HIV serologies were negative. Abdominal ultrasound showed a homogeneous liver. There were no dilations of the bile ducts. Antimitochondrial antibodies were negative and the histological examination confirms diagnosis.
Conclusion:
Progress was good with ursodesoxycholic acid even if interval is short (5 months of evolution).
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