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Tramadol-associated pericarditis.

M J Krantz, J A Garcia, P S Mehler

    International Journal of Cardiology
    |March 18, 2005
    PubMed
    Summary
    This summary is machine-generated.

    Tramadol, a pain medication, may be associated with acute pericarditis. This rare adverse event resolved after discontinuing the drug, suggesting a potential link for clinicians to consider.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Tramadol (Ultram) is a widely prescribed analgesic for moderate to severe pain.
    • Known adverse effects of tramadol include seizures and serotonin syndrome.
    • A link between tramadol and pericarditis has not been previously documented.

    Discussion:

    • This report details an 88-year-old male who developed acute pericarditis shortly after initiating tramadol.
    • The temporal association and symptom resolution upon discontinuation suggest tramadol as a potential cause.
    • This case highlights a previously unreported adverse effect of tramadol.

    Key Insights:

    • Tramadol use may be associated with the development of acute pericarditis.
    • The temporal relationship and dechallenge suggest a drug-induced etiology.

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  • Clinicians should consider tramadol as a potential cause of pericarditis in susceptible patients.

    • Outlook:

    • Further research is needed to confirm the association between tramadol and pericarditis.
    • Monitoring for cardiac adverse events in patients taking tramadol is recommended.
    • This finding may inform future prescribing guidelines and patient counseling regarding tramadol risks.