Related Experiment Video
Updated: Aug 19, 2026

Recapitulation of an Ion Channel IV Curve Using Frequency Components
Published on: February 8, 2011
[ROC (receiver operating characteristics) curve: principles and application in biology]
H Delacour1, A Servonnet, A Perrot
1Laboratoire de biochimie, toxicologie cliniques, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris, France. h_delacour@yahoo.fr
Abstract:
Laboratory test's diagnostic performances are generally estimated by means of their sensibility, specificity and positive and negative predictive values. Unfortunately, these indices reflect only imperfectly the capacity of a test to correctly classify subjects into clinically relevant subgroups. The appeal to ROC (receiver operating characteristic) curve appears as a tool of choice for this evaluation. Used in the medical domain since the 60s, ROC curve is a graphic representation of the relation existing between the sensibility and the specificity of a test, calculated for all possible cut-off. It allows the determination and the comparison of the diagnostic performances of several tests. It is also used to consider the optimal cut-off of a test, by taking into account epidemiological and medical - economic data of the disease. Used in numerous medical domains, this statistical tool is easily accessible thanks to the development of computer softwares. This article exposes the principles of construction and exploitation of a ROC curve.
More Related Videos
09:11Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
Published on: October 2, 2017
10:16Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
Published on: July 13, 2015
Related Concept Videos
Receiver Operating Characteristic Plot
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical, 7TM, or...
Characteristics of Series Resonant Circuit
Signal Sequences and Sorting Receptors
Frequency Response of BJT
Low-Frequency Response: At low frequencies, the behavior of the BJT is determined by its DC bias point, which is set by the...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include: