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Updated: Aug 19, 2026
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Clear cell odontogenic carcinoma: a comprehensive analysis of treatment strategies
Charles S Ebert1, Marc G Dubin, Craig F Hart
1Department of Otolaryngology-Head and Neck Surgery, CB# 7070, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7070, USA. cebert@med.unc.edu
Background:
Odontogenic neoplasms of predominately clear cells are unusual. They represent a diagnostic dilemma, and as a result, treatment strategies are diverse. Our goal is to present two new cases, summarize reported cases of clear cell odontogenic carcinoma (CCOC), assess potential risk factors for recurrence, and propose definitive surgical and therapeutic strategies.
Methods:
A literature search and analysis was performed. Regression models were used to predict risk factors for recurrence.
Results:
Forty-three cases of CCOC were reviewed, including two reported here. The overall rate of recurrent disease was 55%. Local recurrence rates were higher for curettage (80%) than for resection alone (43%). Age (p = .20), sex (p = .28), and tumor site (p = .50) did not predict risk for recurrence.
Conclusions:
CCOC is a potentially aggressive tumor with a tendency for recurrence. Treatment strategies should be directed toward wide surgical resection with confirmation of tumor-free margins. Lymph node dissection and adjuvant radiation therapy should be considered in selected cases.