Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triptolide loaded solid lipid nanoparticle hydrogel for topical application.

Zhinan Mei1, Qunrong Wu, Sheng Hu

  • 1Chemistry and Life Science of South-Central University of Nationalities, Wuhan, PR China. meizhinan@163.com

Drug Development and Industrial Pharmacy
|March 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specific microbial biomarkers for distinguishing saliva from vaginal secretions: Integration of 16S rRNA sequencing and real-time quantitative PCR.

Forensic science international·2025
Same author

Multi-Channel Temporal Interference Retinal Stimulation Based on Reinforcement Learning.

IEEE journal of biomedical and health informatics·2025
Same author

Cancer Cell-Secreted miR-33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis.

Journal of extracellular vesicles·2025
Same author

Development and validation of a CT-based multi-omics nomogram for predicting hospital discharge outcomes following mechanical thrombectomy.

Frontiers in neuroscience·2025
Same author

Pharmacological actions and applications of safflower flavonoids.

Frontiers in nutrition·2025
Same author

Establishment and application of a triplex RTqPCR assay system for the identification of forensic body fluids.

Forensic science international. Genetics·2025
Same journal

Preparation and Characterisation of Pre-Nanoemulsions Encapsulating Multiple Oil-Soluble Active Substances.

Drug development and industrial pharmacy·2026
Same journal

Synergistic anticancer potential of andrographolide and paclitaxel: a dose-reduction strategy to minimize toxicity and enhance therapeutic efficacy.

Drug development and industrial pharmacy·2026
Same journal

Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy.

Drug development and industrial pharmacy·2026
Same journal

Biocompatible and bio-orthogonal surface engineering of inorganic self-assembled nanocrystals for precision drug targeting: a review.

Drug development and industrial pharmacy·2026
Same journal

Next-generation drug delivery for age-related macular degeneration: promise of controlled release formulations.

Drug development and industrial pharmacy·2026
Same journal

Design, optimization, and evaluation of ferulic acid-loaded cubosomal cream for enhanced topical delivery and anti-hyperpigmentation efficacy.

Drug development and industrial pharmacy·2026
See all related articles

Solid lipid nanoparticles (SLNs) enhance triptolide (TP) skin penetration and anti-inflammatory effects. This novel SLN hydrogel formulation improves TP delivery, minimizing toxicity for better therapeutic outcomes.

Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Dermatology

Background:

  • Triptolide (TP) exhibits potent anti-inflammatory, antifertility, antineoplastic, and immunosuppressive activities.
  • Clinical application of TP is hindered by poor water solubility and significant toxicity.
  • Controlled-release systems, like solid lipid nanoparticles (SLNs), offer a promising solution to overcome TP's limitations.

Purpose of the Study:

  • To develop and characterize novel solid lipid nanoparticle (SLN) formulations for enhanced transdermal delivery of triptolide (TP).
  • To evaluate the anti-inflammatory efficacy and safety profile of TP-loaded SLN hydrogels compared to conventional TP hydrogels.

Main Methods:

  • Preparation and characterization of TP-loaded SLNs using tristearin glyceride, soybean lecithin, and PEG400MS.

Related Experiment Videos

  • Optimization of SLN formulation for particle size, polydispersity index (PI), and zeta potential.
  • Incorporation of optimized SLNs into a hydrogel matrix.
  • In vitro evaluation of transdermal absorption and anti-inflammatory activity.

    • Main Results:

    • Optimized SLNs exhibited a particle size of 123±0.9 nm, PI of 0.19, and zeta potential of -45 mV.
    • SLN hydrogel maintained nanoparticulate structure without aggregation.
    • Cumulative transdermal absorption of TP was significantly higher with SLN hydrogel (73.5%) compared to conventional hydrogel (45.3%) over 12 hours.
    • The anti-inflammatory effect of SLN hydrogel was more than double that of the conventional TP hydrogel.

    Conclusions:

    • Solid lipid nanoparticles (SLNs) are effective carriers for enhancing triptolide (TP) transdermal delivery.
    • The developed SLN hydrogel formulation improves TP absorption and significantly boosts anti-inflammatory activity.
    • This novel delivery system offers a safer and more effective approach to TP administration, potentially minimizing toxicity.