Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bubble CPAP: is the noise important? An in vitro study.

J Jane Pillow1, Javeed N Travadi

  • 1Centre for Child Health Research, The University of Western Australia, Perth, 6008 Western Australia, Australia. janep@ichr.uwa.edu.au

Pediatric Research
|March 19, 2005
PubMed
Summary

Bubble Continuous Positive Airway Pressure (CPAP) uses noisy pressure waves to help open infant lungs. Higher bias flow and lower lung compliance increase this noise, potentially improving lung volume recruitment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward a Harmonized Bronchopulmonary Dysplasia Definition: An International Delphi Process.

Pediatrics·2026
Same author

Prognostic Accuracy of BPD Definitions for Long-Term Outcomes in Preterm Infants: A Systematic Review.

Pediatrics·2025
Same author

Multipotent adult progenitor cell therapy: Effect of timing and frequency on lung health in preterm lambs during inflammation.

Pharmacological research·2025
Same author

The Lancet Child & Adolescent Health Commission on the future of neonatology.

The Lancet. Child & adolescent health·2025
Same author

Diaphragm Function in Very Preterm Infants at 36 Weeks' Postmenstrual Age.

Pediatric pulmonology·2025
Same author

Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants: The PLUSS Randomized Clinical Trial.

JAMA·2024

Area of Science:

  • Neonatal Medicine
  • Respiratory Physiology
  • Biomedical Engineering

Background:

  • Continuous Positive Airway Pressure (CPAP) is a key noninvasive respiratory support for infants with Respiratory Distress Syndrome.
  • Effective CPAP therapy relies on recruiting atelectatic lung regions and maintaining adequate lung volumes.
  • Bubble CPAP generates a noisy pressure waveform that may enhance airway opening through stochastic resonance.

Purpose of the Study:

  • To investigate how applied bias flow and lung mechanical properties influence the noise characteristics in bubble CPAP.
  • To determine the impact of varying bias flow and lung compliance on pressure fluctuations within an in vitro lung model.

Main Methods:

  • An in vitro model lung was used to simulate neonatal respiration.

Related Experiment Videos

  • Bias flow was varied between 6-10 L/min.
  • Lung compliance was adjusted between 0.1-1.5 mL/cm H2O to assess its effect on pressure oscillations.

    • Main Results:

    • Increasing bias flow significantly increased the mean and magnitude of pressure oscillations at the airway opening and within the lung model.
    • Decreasing lung compliance amplified the magnitude and frequency content of pressure oscillations in the lung model.
    • Both applied flow and lung mechanics were found to influence the superimposed noise on the CPAP pressure waveform.

    Conclusions:

    • Applied bias flow and lung mechanics are critical determinants of the noise magnitude and frequency in bubble CPAP.
    • The observed influence on pressure oscillations suggests a mechanism by which bubble CPAP may promote lung volume recruitment.
    • Understanding these factors can optimize bubble CPAP settings for improved respiratory support in infants.