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Updated: May 11, 2026

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The Lancet Child & Adolescent Health Commission on the future of neonatology

Daniele De Luca1, Neena Modi2, Peter Davis3

  • 1Physiopathology and Therapeutic Innovation INSERM-U999, Paris Saclay University, Paris, France; Division of Paediatrics and Neonatal Critical Care, "A. Beclere" Medical Centre, APHP-Paris Saclay University, Paris, France.

The Lancet. Child & Adolescent Health
|June 28, 2025
PubMed

Insights

Neonatal mortality remains high due to lagging innovation in treatments for sick newborns. A new roadmap calls for global collaboration to accelerate research and development for better neonatal outcomes.

Area of Science:

  • Neonatology
  • Pediatric Health
  • Medical Innovation

Background:

  • Neonatal mortality rates remain high globally, despite improvements in infant survival.
  • Persistent comorbidities in neonates have lifelong health implications.
  • The current research and development ecosystem hinders progress in neonatal care, particularly for preterm and critically ill infants.

Purpose of the Study:

  • To address challenges in neonatal research and development.
  • To design a roadmap for accelerating innovation in neonatal care.
  • To improve health outcomes for neonates worldwide.

Main Methods:

  • Convened the Lancet Child & Adolescent Health Commission on the future of neonatology.
  • Analyzed multifactorial challenges including leadership, collaboration, regulation, funding, and commercial viability.
  • Developed strategies to accelerate research and development for neonatal drugs and medical devices.

Main Results:

  • Identified significant lagging innovation in the neonatal R&D ecosystem.
  • Highlighted multifactorial public health challenges impeding progress.
  • Proposed a roadmap for future neonatal care advancements.

Conclusions:

  • Urgent need for investment in effective drug and medical device development pathways for neonates.
  • Call for dynamic collaborations among regulatory agencies, governments, funders, industry, and researchers.
  • Emphasized the importance of engaging patients, families, and advocacy groups for health equity in neonatology.

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