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Updated: Aug 19, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Impact of parathyroidectomy on bone histology]
Aiji Yajima1, Tsunamasa Inou, Yoshihide Ogawa
1Department of Urology, Towa Hospital.
Abstract:
Impacts of total parathyroidectomy and autotransplantation on bone histology were evaluated in secondary hyperparathyroidism. Low turnover bone disease accompanied with fibrous tissue developed at 4 weeks after surgery, and osteoclasts disappeared. In addition, fibrous tissue also disappeared at 12 weeks. Even though serum PTH level indicated quite low in some cases, bone resorption exceeded bone formation at 1 years after surgery. So we should pay special attention to the decrease in bone mineral density in the long term in these cases.
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