[The effect of bisphosphonates by systemic administration for periodontal treatment]

Bisphosphonates are widely utilized in the management of systemic metabolic bone diseases such as osteoporosis. The medical action has the abilities both in inhibition of bone resorption and promotion of mineralization on the metabolism of hard tissues. There exists a possible use for bisphosphonates in the periodontal treatment. Therefore, various types of studies have been done for periodontal treatment, and it was shown that bisphosphonates inhibit alveolar bone resorption caused by periodontitis, control flap-induced bone loss and enhance the alveolar bone regeneration after GTR treatment. However, it further detailed studies are required for the clinical application of bisphosphonates to periodontal treatment.