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Updated: Aug 19, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Roles of parathyroid hormone (PTH) on phosphate metabolism]
Mikiko Ito1, Hiroko Segawa, Kenichi Miyamoto
1Department of Nutrition, School of Medicine, Tokushima University.
Abstract:
Changes in the extracellular concentration of inorganic phosphate (Pi) modulate cellular function in a physiologically relevant manner. High serum Pi leads to an increase in PTH secretion, PTH mRNA stability, and parathyroid cell (PT) proliferation. The reduced Pi reabsorption is achieved by a removal of type II a NaPi co-transporter from apical membrane. Acute internalization in response to high dietary Pi-intake or administration of PTH is via clathrin-coated structures and is followed by subsequent lysosomal degradation. In this review, the effects of PTH on the metabolism of Pi are discussed.
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