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Updated: Aug 19, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[The prediction of high-risk patients for secondary hyperparathyroidism]
1Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine.
Abstract:
In patients with chronic renal failure (CRF), the degree of secondary hyperparathyroidism varies greatly. This may be explained, at least in part, by genetic differences. Some bone metabolism-related gene polymorphisms have been suggested to play a key role in the pathogenesis of secondary hyperparathyroidism in uremia. They are mainly associated with parathyroid hormone secretion and/or progression of parathyroid hyperplasia in patients with chronic renal failure, as well as in hemodialysis patients. Further studies might allow us the prediction of high-risk patients for this important complication.
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