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Updated: Jul 31, 2026

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity
Published on: February 24, 2017
[Differentiation of cartilage stem cells and their clinical applications]
1Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University.
Abstract:
In the embryonic development of skeletal elements, cartilage appears to form through the cellular condensation at a particular region within mesenchymal tissues. During this process, cartilage stem cells (or chondroprogenitor cells) pass through several distinct cellular stages, which are regulated by a variety of growth and differentiation factors. In contrast to embryos, chondrogenesis rarely occurs in vivo after birth, except in the process of fracture healing or, to a limited extent, repair of articular cartilage. Full-thickness defects that penetrate articular cartilage are filled with fibrous tissue, fibrocartilage, or rarely with hyaline cartilage. Here we discuss ongoing attempts to induce chondrogenesis for the future therapeutic applications.
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