[Effect of statins: HMG-CoA reductase inhibitor on bone metabolism]

Since G. Mundy first reported in 1999 that a statin has bone forming action by increasing production of BMP-2 and accelerates proliferation and differentiation of osteoblast, many experimental and clinical studies have been performed. The mechanism of action may be mediated by inhibition of HMG-CoA reductase, but further studies may be needed. BMD is not increased remarkably with the dosage used for the treatment of hyperlipidemia, but some studies showed the effect of reducing fractures. There is a report showing the negative results also. Statins may not only help to clarify the physiology of bone but also serve as another way of treatment of osteoporosis.