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Updated: Aug 19, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
[Inhibitory effects of bisphosphonate on vascular calcification]
1Discovery Res. Lab.II, Research Div., Sumitomo Pharmaceuticals Co. Ltd.
None:
Recently, it has been hypothesized that vascular calcification is an actively regulated process in which vascular smooth muscle cells (VSMCs) acquire osteoblast-like functions. Bisphosphonates prevent in vitro calcification of VSMCs and probably inhibit phosphate transport by sodium dependent phosphate transporter which plays a key role in VSMCs calcification. The effects of bisphosphonate on VSMCs have important implications for the future management of patients with vascular calcification.
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