Related Experiment Video
Updated: Aug 19, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
[Therapeutic vaccination approach against pathological bone disease]
1Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo.
Clinical Calcium
|March 19, 2005
Abstract:
RANKL is a membrane-bound cytokine, which plays an important role in osteoclast differentiation and activation. We established a novel therapeutic approach against pathological bone resorption using RANKL vaccine. Administration of RANKL vaccine induced a rapid anti-RANKL antibody induction in mice, and efficiently suppressed bone destruction in arthritis model mice, and bone loss in ovariectomized mice.
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