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[Puberty and bone metabolism].

Hiroyuki Tanaka1

  • 1Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry.

Clinical Calcium
|March 19, 2005
PubMed
Summary

Peak bone mass is established during puberty, influenced by estrogen. While estrogen

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Area of Science:

  • Endocrinology and Bone Metabolism
  • Reproductive Endocrinology

Context:

  • Puberty is a critical period for achieving peak bone mass.
  • Bone mineral accrual rates peak between ages 11-14, with attainment by 16 due to pubertal delays in boys.
  • Estrogen significantly influences bone accrual and sexual dimorphism in bone during this period.

Purpose:

  • To highlight the importance of estrogen in male bone metabolism.
  • To underscore the current lack of understanding regarding androgen's role in bone health.
  • To investigate the hormonal regulation of bone mass accrual during puberty.

Summary:

  • Peak bone mass is largely determined during puberty, with bone accrual influenced by estrogen.
  • Studies on hypogonadal disorders reveal estrogen's crucial role in male bone metabolism.
  • The specific functions of androgens in bone metabolism remain largely unknown.

Impact:

  • Informs understanding of hormonal influences on bone health in both sexes.
  • Identifies a knowledge gap in androgen's role in male bone metabolism.
  • Suggests potential therapeutic targets for bone disorders.

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